Neurofibromatosis Case Essay Example for Free

Neurofibromatosis Case Essay Effects / Symptoms Neurofibromatosis causes a deficiency targeting the nervous system as part of a genetic disorder. The two most common types are abbreviated into NF1 and NF2. NF1 is characterized by cafà © au lait spots, or patches of tan and light brown skin. Another characteristic would be neurofibromas, which are soft, fleshy growths that grow on the skin, and in some cases, under it. The disorder also enters the skeletal level and enlarges and distorts bones as well as adds curvature to the spine. Occasionally tumors develop on the brain or spinal cord. Half of the people with NF1 also inhibit learning disabilities. The less common disorder, NF2, characterizes itself by multiple tumors on cranial and spinal nerves. Hearing loss will nearly inevitably occur in the early teens for people with NF2. Genetic Cause Most commonly Neurofibromatosis is passed on by family members through genes. However, 30 to 50% of newly diagnosed people have no family history of the condition, which can be attributed to a spontaneous mutation in the gene. Once this mutation has occurred, future generation will be at risk of getting the disorder. Genetic Cause The causes of Nf1 are a mutation on the 17 chromosome at q11.2. The mutation mainly affects the development of nerve cells and tissues. The changes in nerve tissues cause tumors or other abnormalities. The tumors can be harmless, in some situations. Nf1 is dominant and autosomal; meaning it will affect males and females equally. Nf2 is a slightly different. Nf2 is characterized by a mutation on the 22q12.2 chromosome. Nf2 is also autosomal dominant. The mutations has significant physical causes consisting of meningiomas and other symptoms consisting of a lot of big words that not even spell check understands. The main idea of the symptoms is that they’ll grow deformities, usually internally, on the spinal cord and other nerve tissues. These deformities can result in loss of hearing, blindness, etc. Treatment/Cure There is no cure for each Nf1 and Nf2, so tough luck if you have it, but there is some good news. Type one of neurofibromatosis is less potent than type two because type two forms tumors on spinal tissue, brain tissue, and other nerve tissue that cause problems to motor skills, with this knowledge it can be concluded that surgery is the best course of treatment for type two. Surgery focuses on removing these tumors, increasing the effectiveness of the effected nerves. However false hope is not being circulated through this class brochure and it should be known that surgery will not serve as a cure, only an attempt to reduce the symptoms of the disease. For type one surgery can be used for treatment, however because the tumors don’t affect nerve tissue the surgery won’t be as an effective treatment. It should be noted that new laser techniques have been promising, however nothing has completely removed the cafà © au lait spots, so if your aiming to get rid of those than your luck hasn’t come through for you, because no technique has permanently removed them. Chemotherapy has been used for this disease, but is widely controversial. However it simply comes down to a personal decision. Work Cited – Websites OMIM Entry # 162200 NEUROFIBROMATOSIS, TYPE I; NF1. OMIM Entry # 162200 NEUROFIBROMATOSIS, TYPE I; NF1. John Hopkins University, n.d. Web. 18 Feb. 2013. Evans, D. Gareth. Summary. Neurofibromatosis 2. U.S. National Library of Medicine, 14 Oct. 1998. Web. 18 Feb. 2013. NINDS Neurofibromatosis Information Page. Neurofibromatosis Information Page: National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 18 Feb. 2013. Work Cited – Book Rubenstein, Allan E., Richard P. Bunge, and David E. Housman. Neurofibromatosis. New York, NY: New York Academy of Sciences, 1986. Print. DiSimone, Ronald E., and Arnold T. Berman. Neurofibromatosis. Philadelphia: Lippincott, 1989. Print.

Globalisation Effect on Singapore

Globalisation Effect on Singapore Globalization can be described as an ongoing process where resources, believes, ideas and technology from different cultures are integrated to each other and promote new ways of thinking and practices among the society. As a continuing progression, globalization aroused from the influences of other cultures, which has been adapted with the local cultural conditions and modified to fit in the context of social behaviour. The external influences will directly override some local particularities, and the culture itself will be altered, or maybe damaged, or even enhanced, according to the perspective of society life. Therefore, the expression of culture itself will be interpreted and analysed in different way which encouraged the people to think, act, and learn the new disciplines in every aspect of life. These processes, hence, have an outcome of a cultural diversity, in which introducing the local values in global culture. In other words, it offered a global and local linkage of social changes that happened in the nation. Looking through the contemporary social life, globalization has become a major issue all over the world. Many countries have developed new approaches in most of the living aspects, and transformed peoples lifestyle in order to follow the major flow that happened globally. In todays modern days, globalization can act as a tool to open the opportunities of influence by other countries, and expand the cross-cultural interaction that may build up the cohesion among the nation. Globalization, however, implies to westernization in present days. The nature of western countries seems to appear as a science based tradition and the world is highly developed towards that tradition, as a sense of control. These global forces appear to superficially standardized and homogenized cultures, and equivalent to westernization. Majority of cultures are converging to the western standards, local identities have been replaced with global culture, and western values have become significant trends in this modern world. Looking at Singapore, a cosmopolitan city, where variety of cultures merges together, is one of a good example of a country that embraces globalization. Besides accepting the westernization, Singapore has been spanning borders through other cultures, such as Malay, Chinese, Indian, and Caucasian. These four interwoven cultures has created a genuine blending of traditions, believes, and ideas. A fusion of cultures in which Singapore brought in, has created a multi-disciplinary notions and practices, rooted in many cultural traditions. This synthesis has altered and transforms the peoples way of life according to the local context. On the other hand, not only western value that the world, including Singapore, has been developing on, but also majority of the countries have welcoming influences from Asian culture. Japan has brought a significant shift in the worlds globalization. Beside westernization, it has been become a popular culture among the world. Japanese culture has generated a different approach in global trends. Its tradition does not rest on science based technology and for them technology is a choice, not a necessity. Japan has greatly developed their long standing traditions towards something that instinctive rather than rationalistic way of thinking, like what the western do. Japan has its own original characteristic, which has a capacity to adapt and integrate new forms and function. Hence, there is no doubt that Japanese influence has an impact on the worlds culture, such as, in space, design, architecture, style, and even food culture. There is no large city in the world in which a Japanese restaurant cannot be found. Far from being a passing fad, Japanese cuisine is an establishment item in restaurants all over the world. The popularity of Japanese food is in part due to its reputation as a healthy alternative and also the curiosity and willingness to constantly introducing new tastes in their daily meals. Japanese way of dining, since the olden days, has put emphasized on food arrangement as a piece of art. For the Japanese, food must be enjoyed visually and pleasing to the eyes. They have developed the aesthetic sense to design exquisite harmony between colours, texture and shape throughout the food arrangement. This visual pleasure is an essential prelude and accompaniment to the savoury pleasure that follow. The influence of Japanese cuisine has been successfully creating a new atmosphere in Singapore food culture. It is proven that Singapore people accepted the taste and ambience of Japanese food by looking to the increasing number of sushi chain restaurant, such as Sushi Tei, Sakae Sushi; numerous traditional and contemporary Japanese restaurant, and also Japanese themed food court such as Ishimura and Manpuku. The diversity of food which has been influenced by Japanese cuisine, has become an inspiration for the designers to introduce innovative and exciting solutions to design dining spaces, through the essential aspect of Japanese dining and design in new ways that suit todays restaurant-goers. Recognizing the context of social behaviour in Singapore, innovation is the key elements for Singaporean. In terms of food culture, people like an excitement and it is a challenge for them to try something fresh and different, both in food and also ambience of dining space. Experience is another strong point, another extra ordinary atmosphere can attract people to get in and try a new restaurant. Besides the tendency to look for new things, the image of Singapore as a fast paced country gave an impact to the society. The time-oriented and multi-tasking people have built a busy working environment and hectic lifestyle in this metropolis city. Consequently, they are likely dont have time to have the luxury of enjoying social fellowship during the weekdays. This could be why it seems that forms of entertainment in Singapore tend to be designed to fit peoples activity on weekends. The big leisure activity that Singapore offers is shopping. There are numerous numbers of malls and shopping centres have been build or even renovated to drag people in the shopping as an attraction. Other than shopping; casinos, theme parks, nature reserves, are the other forms of leisure that Singapore provided. Despite the fact that all those type of facilities can serve as a very relaxing and stress relieving activity, people need to spend their time on weekend to do these activities.

Harley Davidson :: Business Management Essays

Overview Harley-Davidson’s management had much to be proud of as the company wrapped up its Open Road Tour centennial celebration that began in July 2002 in Atlanta, Georgia, and ended on the 2003 Memorial Day Weekend in Harley’s hometown of Milwaukee, Wisconsin. The 14-month Open Road Tour drew large crowds of Harley owners in each of its five stops in North America and additional stops in Australia, Japan, Spain, and Germany. Also during its 2003 centennial year, Harley-Davidson was named to Fortune’s list of â€Å"100 Best Companies to Work For† and was judged third in automotive quality behind Rolls-Royce and Mercedes-Benz by Harris Interactive, a worldwide market research and consulting firm best known for the Harris Poll. The company’s revenues had grown at a compounded annual rate of 16.6% since 1994 to reach $4.6 billion in 2003—marking its 18th consecutive year of record revenues and earnings. In 2003, the company sold more than 290,000 motor cycles, giving it a commanding share of the 651+cc motorcycle market in the U.S. and the leading share of the market in the Asia/Pacific region. The consistent growth had allowed Harley-Davidson’s share price to appreciate by more than 15,000% since the company’s initial public offering in 1986. In January 2004 the company’s CEO, Jeffrey Bleustein, stated that Harley-Davidson’s earnings growth rate should fall in the mid-teens for the foreseeable further and the company expected to increase unit sales to 400,000 units by 2007. However, not everyone was as bullish *This teaching note reflects the thinking, insight, and analysis of case authors, Professor John E. Gamble and Diplom-Betriebswirt Roger Schà ¤fer, both of the University of South Alabama. on Harley-Davidson’s future, with analysts pointing out that the company’s plans for growth were too dependent on aging baby boomers. The company had achieved its record growth during the 1990s and early-2000s primarily through the appeal of its image with baby boomers in the U.S. There was some question how much longer boomers would choose to spend recreational time touring the country by motorcycle and attending motorcycle rallies. The company had yet to develop a motorcycle that appealed in large numbers to motorcycle riders in their 20s or cyclists in Europe who both preferred performance oriented bikes rather than cruisers or touring motorcycles. Another concern of analysts watching the company was Harley-Davidson’s short-term oversupply of certain models brought about by the 14-month production run for its 100th anniversary models.

An Unexpected Message from Our Past :: Barker Regeneration Essays

"An Unexpected Message from Our Past" Who decides that being different is a trait to be looked down upon? In the late 19th century, it was the English Parliament with the passage of the Criminal Law Amendment Bill, specifically outlawing all forms of male homosexual expression. This law, combined with the already negative attitude surrounding the gay community before and after World War I, implied that homosexuality was something to be ridiculed and scorned. This trend unfortunately continues yet over a century later. Pat Baker's Regeneration, starting on page 54 and continuing throughout the novel, repeatedly uses a non-fictional character, Siegfried Sassoon, to exhibit the unnecessary hurt that homosexuals experienced throughout history, an angle that was often neglected when homosexuals were discussed one hundred years ago. Regeneration displays the conflict that many homosexuals are tormented by when deciding whether to live for themselves and their personal needs or whether to conform in order to blend in with socie ty. In the late 19th century, the purity movement was well underway in England. Serious efforts made by those involved in legislation were creating "a climate where immorality could be tackled seriously" (Mort 114). With the passage of the Criminal Law Amendment Bill in 1885, the first steps were taken toward an "improved moral climate in the country" (Mort 129). While this new law included some positive improvements such as elevating the age of sexual consent for women from 13 to 16, a surprising addition was made just before the final vote was taken in Parliament. Henry Labouchere, a liberal in the House of Commons, introduced a clause "outlawing all forms of male homosexual contact" (Mort 129). The public embraced the addition and the "general negative attitude toward homosexuality" continued to grow with the law on its biased side as well (Robb 57). Ten years later, circumstances for homosexual males continued to look grim. On May 25, 1895, Oscar Wilde, a renowned playwright, was found guilty of engaging in homosexual activity and sentenced to the maximum punishment allowed: imprisonment for two years with hard labor. The judge, disgusted with Wilde, declared, "People who can do these things must be dead to all sense of shame," and he deemed the sentence inapt for such a vial criminal (Barger). In the years following, little change was made to ease the growing tension. When Edward Carpenter published his book The Intermediate Sex in 1909, he encouraged the acceptance and understanding of people with different sexual preferences and practices than those who found themselves in the majority.

William the Conqueror :: essays research papers

He was the son of Robert, Duke of Normandy, his mother, Herleva, the daughter of a tanner of Falaise. In 1035 William’s father Robert, Duke of Normandy, went on a pilgrimage to the Holy Land, in which he died. Before starting the pilgrimage, he presented to the nobles his seven year old child demanding their allegiance. "He is little", the father said, "but he will grow, and, if God please, he will mend." William, after a period of anarchy, became the ruler of Normandy in his father's place at the age of nine. William had a youth of clean life and of much natural piety, while the years of storm and stress through which he passed gave him an endurance of character which lasted to his life's end. During the time of anarchy in Normandy he became a skilled military leader and defeated his enemies, uniting his duchy. Once he began fighting, rumor has it that he never lost a battle. In 1047 a serious rebellion of nobles occurred, and William with the aid of King Henry of France, gained a great victory at Val-à ¨s-Dunes, near Caen. Which led to the capture of the two strong castles of Alenà §on and Domfront. Using this as his base of operations, the young duke, in 1054 made himself master of the province of Maine and became the most powerful vassal of the French Crown, able on occasion to bid defiance to the king himself. William even married Matilda, the daughter of the Earl of Flanders, in 1053,in spite of the papal prohibition. In 1066 when his claim to the English throne was threatened by Harold Godwinson. Due to the fact that Harold Godwinson overlooked the dead king's wishes. Edward the Confessor, sworn his loyalty to William of Normandy when he died not to Harold. Harold Godwinson promptly had himself proclaimed king. It was only a matter of months before William, Duke of the large and powerful duchy of Normandy in France, paid Harold a visit to bring to his remembrance his own claim to the throne. William raised an army of Normans by promising them land and wealth when he came into his rightful kingship. October 14th 1066 he and William fought at the famous battle of Hastings. William and his army of Normans came, saw, and conquered. True to his promise to his fellow warriors, William systematically replaced the English nobility with Norman barons and noblemen who took control of the land, the people, and the government.

Corporate Strategy Essay

Diversification is even more prominent in other parts of the world †¢ Grupos, chaebol, business houses, keiretsu, and so on – Poor corporate strategy is common â€Å"Excite, one of the leading Internet services companies, yesterday [received a] takeover offer from Zapata, a Texas-based group with holdings in marine protein and food packaging companies. Citing the â€Å"excellent fit with Zapata’s new strategic direction,† Avram Glazer, Zapata’s chief executive officer, said the proposed transaction â€Å"makes sense for Excite’s shareholders because of the capital resources that Zapata can bring to Excite. † Financial Times, May 22, 1998 2 What diversified corporation did this become? 3 Decomposition of Variance in Profitability: Evidence from the United States Year 2% Industry 18% Corporate parent 4% Transient 46% †¢ In the U. S. corporate strategy is typically the icing on the cake, not the cake itself – Business units must be competitive on their own merits – †¦in attractive industries †¢ But the icing can make the decisive difference between a good cake and a bad one Business segment 30% Note: Ignores covariance terms; based on 58,132 observations of 12,296 business segments in 628 industries in the United States Source: Anita M. McGahan and Michael E. Porter, â₠¬Å"How Much Does Industry Matter Really? † Strategic Management Journal, 1997 4 Decomposition of Variance in Profitability: Evidence from 14 Emerging Economies †¢ In much of the rest of the world, corporate strategy is more prominent †¢ Membership in a diversified entity has a larger effect on profitability †¢ The effect on profitability is more likely to be positive Source: Tarun Khanna and Jan W. Rivkin, â€Å"Estimating the Performance Effects of Business Groups in Emerging Markets,† Strategic Management Journal, 2000 Countries: Argentina, Brazil, Chile, India, Indonesia, Israel, Mexico, Peru, the Philippines, South Africa, South Korea, Taiwan, Thailand, and Turkey Litmus Test of Corporate Strategy †¢ Is the combination of all businesses of the firm worth more than the sum of how much each business is worth individually? – The answer could be less, e. g. J. C. Penney telemarketing division was worth 3X the market value of the entire firm †¢ When deciding whether or not to acquire another business, you need to decide BOTH – whether you have a competitive advantage running that business – AND how it will contribute to the fit among the other 6 businesses you are running Acrobat Document 7 The Walt Disney Company: Stock Price vs. S&P 500, 1984-1994 8 The Walt Disney Company: Stock Price vs. S&P 500, 1995-2005 9 Two big problems 1. Growth at all costs: †¢ This is an example of what happens when a solid corporate strategy meets an aggressive growth goal 2. Mismatch between strategy and organizational structure: †¢ You can have a corporation with businesses that are closely connected like the classic Disney businesses and then run the businesses together in a tightly integrated way. That can work. †¢ You can have a corporation with the broader scope of later Disney and run them in a loosely coupled way. That can work. †¢ But if you have a corporation with the broader scope of later Disney and run them like the classic Disney, with heavy-handed management from the top, searching for synergy that doesn’t really exist†¦then you get into trouble. – In 2005, ABC President Robert Iger replaces Eisner 10 The Walt Disney Company: Stock Price vs. S&P 500, 2005-2012 11 The Walt Disney Company: Take-aways Core lessons of corporate-level strategy †¢ Competition occurs at the level of the business unit †¢ Corporate strategy is a success or failure to the extent that it enhances business unit competitive advantage – Is the relative gap between WTP and cost larger than it would be otherwise? †¢ Two tests: – Better-off: Does the presence of the corporation in a given market improve the total competitive advantage of business units over and above what they could achieve on their own? (What’s the added value of the corporation? – Ownership: Does ownership of the business unit produce a greater competitive advantage than an alternative arrangement would produce? †¢ A corporation is more likely to pass the tests when it has some shared resource that (a) creates competitive advantage for the business units and (b) is difficult to trade efficiently via the market – E. g. , access to animated characters – Making business units â€Å"better off† sounds easy, but it typically requires sophisticated structures, systems, and processes, plus cultural supports 12 Corporate strategy entails trade-offs Either focus on†¦ or focus on†¦ Guidance on the Projects Overall Grading †¢ The project must cover all three components of the class – Human and Social Capital – Strategy – Multinational Management Components of Grade (NOT equally weighted) †¢ Use of frameworks (most important issue) †¢ Quality of research †¢ Innovativeness/Insight of analysis †¢ Integration of different components of class †¢ Quality of communication 14 †¢ ? of grade will be based on presentation; ? on final project write up †¢ We will also use a peer assessment to adjust the grade for effort put in by each team member

Teenage Pregnancy in Philippines

Teen pregnancies in the Philippines By Rebecca B. Singson Philippine Daily Inquirer First Posted 00:55:00 06/14/2008 Filed Under: Health, Lifestyle & Leisure, Gender Issues (First in a series) MANILA, Philippines? The sexual revolution has ushered in a period in which the average adolescent experiences tremendous pressures to have sexual experiences of all kinds. Filipino teens get a higher exposure to sex from the Internet, magazines, TV shows, movies and other media than decades ago, yet without any corresponding increase in information on how to handle the input. So kids are pretty much left to other kids for opinions and value formation when it comes to sex. Sexual misinformation is therefore equally shared in the group. Parents at home and teachers in school feel equally inadequate or uneasy to discuss the topic of sex with youngsters. The problem mounts because the barkada (gang) has a more profound influence than parents do and they exert pressure and expect the adolescent to conform to the rest of them. In fact, female adolescents whose friends engage in sexual behavior were found to be more likely to do the same compared to those who do not associate with such peers. If the teen perceives her peers to look negatively at premarital sex, she was more likely to start sex at a later age. Numbers Statistics in the United States show that each year, almost 1 million teenage women? 10 percent of all women aged 15-19 and 19 percent of those who have had sexual intercourse? become pregnant and one-fourth of teenage mothers have a second child within two years of their first. In the Philippines, according to the 2002 Young Adult Fertility and Sexuality Study by the University of the Philippines Population Institute (Uppi) and the Demographic Research and Development Foundation, 26 percent of our Filipino youth nationwide from ages 15 to 25 admitted to having a premarital sex experience. What? s worse is that 38 percent of our youth are already in a live-in arrangement. The 1998 National Demographic and Health Survey (NDHS) reveals that 3. 6 million of our teenagers (that? s a whopping 5. 2 percent of our population! got pregnant. In 92 percent of these teens, the pregnancy was unplanned, and the majority, 78 percent, did not even use contraceptives the first time they had sex. Many of the youth are clueless that even on a single intercourse, they could wind up pregnant. Risks There are many reasons teen pregnancies should be avoided. Here? s a low down on the facts: ? Risk for malnutrition Teenage mothers tend to have poor eating habits and are less likel y to take recommended daily multivitamins to maintain adequate nutrition during pregnancy. They are also more likely to smoke, drink or take drugs during pregnancy, which can cause health problems for the baby. ? Risk for inadequate prenatal care Teenage mothers are less likely to seek regular prenatal care which is essential for monitoring the growth of the fetus; keeping the mother? s weight in check; and advising the mother on nutrition and how she should take care of herself to ensure a healthy pregnancy. According to the American Medical Association, babies born to women who do not have regular prenatal care are 4 times more likely to die before the age of 1 year. Risk for abortion Unplanned pregnancies lead to a higher rate of abortions. In the United States, nearly 4 in 10 teen pregnancies (excluding those ending in miscarriages) are terminated by abortion. There were about 274,000 abortions among teens in 1996. In the Philippines, although abortion is illegal, it would shock you to know that we even have a higher abortion rate (25/1,000 women) compared to the Unite d States where abortion is legal (23/1,000 women). For sure, there are more abortions that happen in our country that are not even reported. Backdoor abortions are resorted to with untrained ? hilots? with questionable sterility procedures, increasing the possibility for tetanus poisoning and other complications. ? Risk for fetal deaths Statistics of the Department of Health show that fetal deaths are more likely to happen to young mothers, and that babies born by them are likely to have low birth weight. ? Risk for acquiring cervical cancer The Human Papillomavirus (HPV) is a sexually-transmitted, wart-forming virus that has been implicated in causing cancer of the cervix. This is the most common cancer in women secondary to breast cancer. Women who are at increased risk for acquiring this are those who engage in sex before 18, have a pregnancy at or younger than 18, or have had at least 5 sexual partners, or have had a partner with at least 5 sexual partners. If you start sex at an early age, you have a higher likelihood of going through several sexual partners before you settle down, thus increasing your exposure to acquiring the virus and acquiring cervical cancer. The men can get genital warts from this virus and can certainly pass it on to their partners, thus increasing her risk for cervical cancer. Is that something you would want to gift to your wife with on your honeymoon? There is a way to test women (HPV Digene test) but no test for the man so you can? t know if you have it. Using the condom does not confer protection against acquiring this virus since the condom cannot cover the testes where the warts can grow and proliferate